Science & Research

Microdosing Protocols: Fadiman, Stamets & Intuitive

The philosophy behind the well-known approaches — and why it's a personal conversation.

Once someone decides to explore microdosing, a practical question follows quickly: how often? The honest answer is that there's no single correct rhythm — but over the years, a few well-known frameworks have emerged. Understanding them helps you approach a practice thoughtfully rather than randomly.

A note before we begin: this article describes philosophies of scheduling, not dosing amounts. How much is a deeply personal matter to work out with a knowledgeable guide, never from a webpage. What follows is about rhythm and intention.

The Fadiman Protocol

Developed by researcher Dr. James Fadiman, this is the most widely referenced approach. The rhythm is gentle and cyclical: a day on, followed by two days off, then repeat. The reasoning is thoughtful — the “off” days let the nervous system integrate and prevent the body from building tolerance. Many beginners are drawn to Fadiman's approach precisely because it builds in rest. It treats microdosing as a cycle, not a daily dependency.

The Stamets Stack

Named for mycologist Paul Stamets, this approach follows a four-days-on, three-days-off rhythm and is often associated with the pairing of complementary natural compounds. It's a more consistent cadence than Fadiman's, and tends to appeal to people who have some experience and want a steadier weekly structure. As with any protocol, more frequent isn't better — it's simply different, and suited to different people.

Intuitive dosing

The third approach is the least prescriptive and, in some ways, the most Lōkahi. Intuitive dosing means listening — noticing when your body and spirit are asking for support, and when they're asking for rest. It requires self-awareness and honesty, because “intuition” can quietly become “habit” if you're not paying attention. For that reason, we generally suggest people begin with more structure and earn their way toward intuition as they come to know themselves in the practice.

Which one is right?

There's no universal answer, and anyone who tells you otherwise is selling something. The right rhythm depends on your goals, your body, your sensitivities, and your life. What matters far more than the specific protocol is the intention and attention you bring to it. A structured schedule followed mindlessly serves you less than a simple one followed with genuine presence.

Whatever rhythm you choose, the single most valuable thing you can do is track your experience. What you write down, you begin to understand — and understanding is where a practice becomes wisdom.

The information provided in this article is for educational purposes only and is not intended as medical advice. Lōkahi Sanctuary does not make medical claims. Our content and offerings are not intended to diagnose, treat, cure, or prevent any disease. Always consult your physician before making changes to your health regimen. Lōkahi Sanctuary is a Private Members Association operating under private and religious law.